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Sixty-four patients with iPAH or PAHassociated with CTD, anorexigen use, or HIV infection wererandomized to receive various doses of ambrisentan (1, 2.5, 5,or 10 mg) once a day for a total duration of 12 weeks.41 The6-MWD improved from baseline with ambrisentan (36.1 m,p < 0.0001) with similar increases for each dose group (range33.9–38.1 m). Warfarin and newer anticoagulants havebeen approved for the prevention of stroke innonvalvular atrial fibrillation. Migraineurs often have considerable neckpain–this is not cervicogenic headache

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